Biophysics of Clathrin Mediated Endocytosis
Guest Lecturer: Dr. Ralph Nossal, Professor, National Institutes of Health, Bethesda, MD
This event will take place from 11:00 a.m. – 11:50 a.m. in Rm 600, 6th floor, Wm. C. Jason Library. Receptor Mediated Endocytosis is a process whereby, for example, mammalian cells take up essential nutrients and hormones from their environments. The process involves the formation of a protein coat on the cytoplasmic side of the plasma membrane, a major constituent of this coat being a unique supramolecular complex known as a clathrin “triskelion. “ A triskelion has the form of a three-legged structure whose identical clathrin heavy chains are joined at their C-termini to a common hub. Under the proper conditions the triskelions can polymerize into polyhedral cages whose edges and faces are like those of a soccer ball. We will review how physical methods such as dynamic light scattering (DLS) and small angle neutron scattering (SANS) can be used to establish certain mesoscopic properties of the triskelions.
All sessions of the seminar series are free and open to the public.
Sponsored by the Optical Sciences Center for Applied Research (OSCAR).For more information on this event, contact Ms. Shonda Poe at (302) 857-6715.
Attachment: Nossal Flyer